Alternative-splicingImmune checkpoint blockade has been a successful treatment for several cancers, particularly in stage 4 melanoma. Unfortunately, it does not work for all patients, neither does it work for all cancers. Given the number of side effects, there is interest in determining which patients will have a durable response to this treatment.
Principal investigatorAndre Wang email@example.com
Area of scienceBiology
Applications usedR, ENCODE pipeline
Partner Institution: The University of Western Australia| Project Code:
This project intends to locate genes that can identify which patients will respond to immune checkpoint blockade. By doing so, patients are not unnecessarily exposed to treatment that may potentially be futile.
The project makes use of mouse cancer models; RNA from mice were sequenced and passed through validated computational pipelines to search for genes that were expressed differently between responders and non-responders.
These pipelines are a computationally expensive process. Resources from the Pawsey Centre allow for the process to be possible; it would otherwise take a prohibitive amount of time.